What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule NNMT inhibitor that has gained attention for its potential effects on metabolism and fat reduction. By inhibiting NNMT (nicotinamide N-methyltransferase), it may enhance energy expenditure and reduce fat accumulation.
Mechanism
NNMT Inhibition
NNMT normally:
- Methylates nicotinamide
- Regulates NAD+ metabolism
- Affects energy balance
- Higher in adipose tissue
Effects of Inhibition
Blocking NNMT may:
- Increase NAD+ levels
- Enhance metabolic rate
- Reduce fat accumulation
- Improve energy expenditure
Research Context
Obesity Research
- NNMT elevated in obese adipose tissue
- Inhibition reduces fat in models
- Metabolic rate enhancement
- Weight management potential
Preliminary Data
Research is early stage:
- Primarily cell and animal studies
- Human data limited
- Mechanism validation ongoing
Note
5-Amino-1MQ is not a peptide but a small molecule often grouped with metabolic research compounds.
Summary
5-Amino-1MQ represents a novel approach to metabolic modulation through NNMT inhibition, with early research suggesting fat-reduction potential.
Key Points:
- Classification: Small molecule NNMT inhibitor
- Mechanism: NNMT inhibition
- Research Focus: Obesity, metabolism
- Status: Early research stage